Vitamin D and mental disorders: update on the latest evidence and focus on autism and anorexia

Alessandro Cuomo, Simone Pardossi, Matteo Cattolico, Giovanni Barillà, Andrea Fagiolini

Department of Mental Health and Sense Organs, University of Siena

DOI 10.30455/2611-2876-2024-2e

Vitamin D, originally associated with calcium regulation and bone health, is emerging as a crucial element within the scope of mental health, not only for disorders such as depression and schizophrenia, but also for autism and eating disorders. The presence of vitamin D receptors in several brain regions suggests that its role in neuroprotection, neurogenesis and neuroimmunological regulation is significant. Vitamin D deficiency in early life is associated with an increased risk of developing schizophrenia and low vitamin D levels have been correlated with depression, and with evidence for the use of vitamin D supplementation in reducing depressive symptoms. Although low vitamin D levels have been observed in children with autism spectrum disorders and mothers during pregnancy, causality is still complex. Patients with eating disorders show vitamin D deficiency, with implications for bone and mental health, and vitamin D may also have a link to impulsivity in these cases.

Vitamin D supplementation may improve some symptoms, but further research is needed to fully understand the underlying mechanisms. This overview emphasises the importance of vitamin D for mental health and the need for further studies to clarify causal relationships and develop more effective therapies for neuropsychiatric disorders.

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